Application of ROAS (Roaccutane, Acnecutane, Isotretinoin)
Oral isotretinoin is best absorbed when taken with high-fat foods because it has a high lipophilicity. Isotretinoin’s effectiveness doubles when taken after a high-fat meal compared to when taken without food. Due to the molecular ratio of isotretinoin to vitamin A, it should not be taken with vitamin A supplements due to the danger of toxicity through cumulative overdose.
You should always take Roaccutane with a full glass of water so that the capsule does not dissolve in the esophagus. Do not chew or suck on the capsule. Swallow it as quickly as possible. The course of treatment usually lasts from 8 weeks to 24 weeks.
It is also used by athletes on the “courses” of anabolic steroids to reduce oily skin and prevent acne.
ROAS dosage (Roaccutane, Acnecutane, Isotretinoin)
It is recommended to start the dosage without a doctor’s prescription at 10 mg per day, with a possible increase. It is not recommended to increase the dosage over 20 mg per day without a doctor’s prescription.
A specific dosage can only be selected by a doctor, in each case individually, because the therapeutic efficacy of the drug and its side effects are dose-dependent and may vary in severity in different people. Typically, treatment is started at 0.1 mg / kg / day. A month later, depending on the tolerance and effectiveness of Isotretinoin, the dose is increased by 0.1-1 mg / kg / day. The average daily dosage is 0.4-0.5 mg per kilogram of the patient’s body weight in 2 divided doses. With a severe course of the disease and with acne lesions of the trunk, it is increased to 2 mg / kg / day. The duration of use of Isotretinoin is from 16 to 24 weeks. If necessary, repeat courses of treatment are carried out at intervals of at least 8 weeks.
ROAS side effects (Roaccutane, Acnecutane, Isotretinoin)
Some side effects are not common, occurring in 1 or more in 10 patients and include:
-helitis (inflammation and chapping of the lips)
-dermatitis (skin inflammation)
These effects vary in severity, frequency, and duration between patients. Using a cream or ointment to moisturize the skin and using lip balm can help relieve dry skin and lips.
Categories of people who should not use isotretinoin:
-children under 12 years old
-pregnant women, or women planning pregnancy in the coming year
– women who are breastfeeding
– people with impaired liver function
-people with high blood fat
– people with hypervitaminosis A – the presence of too much vitamin A in the body, the symptoms of which include:
– skin changes
Isotretinoin should be used with caution in people with:
– dry eye syndrome
– impaired renal function
people who are allergic to peanuts, soy or sugar sorbitol, as some brands of isotretinoin may contain these ingredients