Nolvadex (Tamoxifen) or Clomid differences:
Nolvadex (tamoxifen) also does not affect the level of estrogen in the blood, because. the mechanism of its action is also reduced to the blockade of estrogen receptors, including in the pituitary gland. However, Clomid is a more selective (selective) blocker, while Nolvadex is less selective. While Clomid binds to estrogen receptors predominantly in the pituitary and testicles, Nolvadex binds to them almost throughout the body. The exception is bone tissue, where clomid and tamoxifen, on the contrary, activate estrogen receptors.
Clomid (Clomid) acts on estrogen receptors in the pituitary and ovaries. By binding estrogen receptors in the pituitary gland, Clomid breaks the negative feedback mechanism, i.e. if usually estrogens, acting on the pituitary gland, reduce the production of FSH and LH, then this does not happen when taking Clomid.
Clomid does not directly affect the level of estrogen in the blood.
Thus, Clomid acts as an estrogen antagonist and eliminates their inhibitory effect on the hypothalamus and pituitary gland, contributing to a faster recovery of their function. Nolvadex blocks receptors in almost all tissues, and also helps the body begin to restore its own testosterone. It is important to note that Nolvadex is able to block estrogen receptors in the pituitary gland to a lesser extent than Clomid.
Clomiphene and tamoxifen do not affect the metabolism of estrogen hormones, therefore, while taking these drugs, estrogens continue to be destroyed by liver enzymes, and do not accumulate in the body.
“Attention” Tamoxifen has disadvantages: quite toxic (sometimes this is manifested by loss of appetite and nausea, the risk of thrombosis increases). Tamoxifen increases the number of progesterone receptors, so it cannot be used if the course is based on progestin drugs (nandrolone, trenbolone). In this case, clomiphene should be used.
How and when to take Nolvadex (tamoxifen)
It is most rational to use aromatase inhibitors during the course, among which Proviron is especially popular, since this drug does not negatively affect the secretion of growth hormone and increases the concentration of anabolic hormones in the blood by suppressing aromatization. In the last week of the course and 2 weeks after, Tamoxifen should be used as the main component of PCT.
In the absence of Proviron, the start of Nolvadex intake falls on the 2nd week of the steroid cycle, and ends 2-3 weeks after the end of the cycle, the average dose is 10-20 mg per day. I would like to pay special attention to a common misconception when antiestrogens are recommended to be drunk after a cycle. The level of estrogen rises at the end of the first week of the cycle, so from this moment you need to start taking it!
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