How and when to take Nolvadex (Tamoxifen):
It is most rational to use aromatase inhibitors during the course, among which Proviron is especially popular, since this drug does not negatively affect the secretion of growth hormone and increases the concentration of anabolic hormones in the blood by suppressing aromatization.
In the last week of the course and 2 weeks after, Tamoxifen should be used as the main component of PCT.
In the absence of Proviron, the beginning of taking Nolvadex falls on the 2nd week of the steroid cycle, and ends 2-3 weeks after the end of the cycle, the average dose is 10-20 mg per day. I would like to draw special attention to a common misconception when antiestrogens are recommended to drink after a cycle. Estrogen levels rise at the end of the first week of the cycle, so this is where you need to start taking it!
“Attention” If anabolic drugs are used that are not subject to aromatization, the need for aromatase inhibitors disappears, while tamoxifen is included only at the end of the course.
Clomid (clomiphene) or nolvadex (tamoxifen):
Clomid (Clomid) acts on the estrogen receptors in the pituitary gland and ovaries. By binding the estrogen receptors in the pituitary gland, clomid breaks the negative feedback mechanism, i.e. if usually estrogens, acting on the pituitary gland, reduce the production of FSH and LH, then when taking clomid this does not happen. Clomid does not directly affect the level of estrogen in the blood.
Nolvadex (Tamoxifen) also has no effect on blood estrogen levels. the mechanism of its action is also reduced to the blockade of estrogen receptors, including in the pituitary gland. However, clomid is a more selective (selective) blocker, while nolvadexe is less selective. If clomid binds to estrogen receptors mainly in the pituitary gland and testes, then nolvadex binds to them in almost the entire body. An exception is bone tissue, where clomid and tamoxifen, on the contrary, activate estrogen receptors.
Thus, clomid acts as an antagonist of estrogens and eliminates their inhibitory effect on the hypothalamus and pituitary gland, contributing to a more rapid restoration of their function. Nolvadex, blocks receptors in almost all tissues, and also helps the body begin to restore its own testosterone. It is important to note that nolvadex is less able to block estrogen receptors in the pituitary gland than clomid.
Clomiphene and tamoxifen do not affect the metabolism of estrogen hormones, therefore, while taking these drugs, estrogens continue to be destroyed by liver enzymes, and do not accumulate in the body.
Tamoxifen has disadvantages: it is quite toxic (sometimes this is manifested by loss of appetite and nausea, the risk of thrombosis increases). Tamoxifen increases the number of progesterone receptors, so it cannot be used if the course is based on progestin drugs (nandrolone, trenbolone). In this case, clomiphene should be used.
Nolvadex (Tamoxifen) is preferred over Clomid (Clomiphene) because:
- Despite its lesser effect on the pituitary gland, Tamoxifen has the same ability to restore testosterone levels as Clomid.
- Tamoxifen blocks the action of estrogens throughout the body, including the pituitary and hypothalamus, which means that it will help not only restore testosterone secretion, but also prevent fluid retention in the body.
- Tamoxifen is significantly cheaper than Clomid
- Tamoxifen lowers cholesterol levels, which is important when using steroids
- Clomid increases the level of globulin, which binds to testosterone, which negatively affects weight gain.